358 SHORT STATURE ASSOCIATED TO SEVERE KNEE OA IN WOMEN

Prevalence of Knee OA in Karate Community in Indonesia

Background. Osteoarthritis (OA) ranks fifth in the most disabling conditions. Karate is an unarmed combat sport that uses hands and feet to deliver and block blows. The karate movements, such as high load and frequent flexion and extension of the knee, make the athletes susceptible to knee injuries and progress to knee OA (KOA). Objectives. The study aims to address the prevalence and risk fac...

Severe Short Stature: an unusual finding in lipoid proteinosis

Lipoid proteinosis (LP) is a rare disorder and it can affect every organ in the body. The clinical manifestations of LP may vary considerably between affected individuals. Short stature is reported in patients with LP however the underlying etiology is not clear. Short stature may be due to endocrine dysfunction caused by deposition of hyaline-like material in endocrine glands. We investigated ...

Knee injury and knee OA

An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome.

CONTEXT Severe short stature can be caused by defects in numerous biological processes including defects in IGF-1 signaling, centromere function, cell cycle control, and DNA damage repair. Many syndromic causes of short stature are associated with medical comorbidities including hypogonadism and microcephaly. OBJECTIVE To identify an underlying genetic etiology in two siblings with severe sho...

Cleidocranial dysplasia: a rare cause of disproportionate severe short stature.

Skeletal dysplasia is an uncommon cause of short stature in children. An 11-year-old girl was evaluated for severe short stature in a tertiary care hospital. Clinical examination revealed severe disproportionate short stature and classical triad of multiple supernumerary teeth, and complete absence of clavicles and open sagittal sutures and fontanelles. Skeletal survey confirmed these findings,...